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Therapeutic Development in the Absence of Predictive Animal Models of Nervous System Disorders
Language: en
Pages: 95
Authors: National Academies of Sciences, Engineering, and Medicine
Categories: Medical
Type: BOOK - Published: 2017-06-24 - Publisher: National Academies Press

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Compared with other disease areas, central nervous system (CNS) disorders have had the highest failure rate for new compounds in advanced clinical trials. Most
Improving and Accelerating Therapeutic Development for Nervous System Disorders
Language: en
Pages: 107
Authors: Institute of Medicine
Categories: Medical
Type: BOOK - Published: 2014-02-06 - Publisher: National Academies Press

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Improving and Accelerating Therapeutic Development for Nervous System Disorders is the summary of a workshop convened by the IOM Forum on Neuroscience and Nervo
Improving the Utility and Translation of Animal Models for Nervous System Disorders
Language: en
Pages: 111
Authors: Institute of Medicine
Categories: Medical
Type: BOOK - Published: 2013-04-25 - Publisher: National Academies Press

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Nervous system diseases and disorders are highly prevalent and substantially contribute to the overall disease burden. Despite significant information provided
Neuroscience Trials of the Future
Language: en
Pages: 111
Authors: National Academies of Sciences, Engineering, and Medicine
Categories: Medical
Type: BOOK - Published: 2016-11-07 - Publisher: National Academies Press

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On March 3-4, 2016, the National Academies of Sciences, Engineering, and Medicine's Forum on Neuroscience and Nervous System Disorders held a workshop in Washin
Animal Models of Cognitive Impairment
Language: en
Pages: 395
Authors: Edward D. Levin
Categories: Medical
Type: BOOK - Published: 2006-06-22 - Publisher: CRC Press

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The costs associated with a drug's clinical trials are so significant that it has become necessary to validate both its safety and efficacy in animal models pri