Download or read book Preclinical Development Handbook, 2-Volume Set written by Shayne Cox Gad and published by Wiley-Interscience. This book was released on 2008-03-14 with total page 2432 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book brings together in one resource an overview of the preclinical process along with a compendium of methods and techniques that need to be considered when developing a new drug. The book details steps in the preclinical process including: prioritizing and optimizing leads, dose formulation, ADME, pharmacokinetics, toxicity, modeling, and regulations. It includes problems that are encountered, solutions to these problems, and limitations of various methods and techniques used in determining the safety and efficacy of a drug at this stage.