Download or read book Synaptic Plasticity and the Mechanism of Alzheimer's Disease written by Dennis J. Selkoe and published by Springer Science & Business Media. This book was released on 2008-01-08 with total page 186 pages. Available in PDF, EPUB and Kindle. Book excerpt: A biochemical hypothesis - that Alzheimer’s disease (AD) is a progressive cerebral amyloidosis caused by the aggregation of the amyloid b-protein (Ab) - preceded and enabled the discovery of etiologies. This volume serves as a record focused on bringing together investigators at the forefront of elucidating the structure and function of hippocampal synapses with investigators focused on understanding how early assemblies of Ab may compromise some of these synapses.