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We next focused on identifying subdomains of the Fas Ligand cytoplasmic tail that are critical for mediating costimulation. Despite the normal surface expressio

Fas Signaling is focused on the signaling mechanisms and biology of the prototypic death receptor Fas, also called CD95 or APO-1. The chapters of this book cove

Binding of Fas Ligand (FasL) to the Fas receptor triggers apoptosis of the receptor-bearing cell, which plays a pivotal role for homeostasis of the immune syste

We have investigated a possible role of Fas ligand (FasL) in reverse signaling to mediate cell survival and growth signals through its intracellular proline-ric