Broadly Neutralizing Antibodies and Broadly Neutralizing Sera
Author | : Laura M. Walker |
Publisher | : |
Total Pages | : 454 |
Release | : 2011 |
ISBN-10 | : OCLC:763618365 |
ISBN-13 | : |
Rating | : 4/5 (65 Downloads) |
Download or read book Broadly Neutralizing Antibodies and Broadly Neutralizing Sera written by Laura M. Walker and published by . This book was released on 2011 with total page 454 pages. Available in PDF, EPUB and Kindle. Book excerpt: Many anti-viral vaccines elicit neutralizing antibodies as a correlate of protection. For HIV-1, given the enormous variability of the virus, it is widely believed that the induction of a broadly neutralizing antibody (bNAb) response will be crucial in a successful vaccine against the virus. There are, however, major challenges in the development of immunogens that elicit bNAbs. Our strategy toward the rational design of an HIV-1 vaccine involves characterizing the epitopes of bNAbs and designing immunogens to re-elicit these types of antibodies.