Download or read book Endotoxin Predictors and Associated Respiratory Outcomes Differ with Climate Regions in the U.S. written by and published by . This book was released on 2018 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Abstract: Rationale: Although endotoxin is a recognized cause of environmental lung disease, how its relationship with respiratory outcomes varies with climate is unknown. Objective: To examine the endotoxin predictors as well as endotoxin association with asthma, wheeze, and sensitization to inhalant allergens in various US climate regions. Methods: We analyzed data on 6963 participants in the National Health and Nutrition Examination Survey. Endotoxin measurements of house dust from bedroom floor and bedding were performed at theUniversity of Iowa . Linear and logistic regression analyses were used to identify endotoxin predictors and assess endotoxin association with health outcomes. Results: The overall median house dust endotoxin was 16.2 EU/mg; it was higher in mixed-dry/hot-dry regions (19.7 EU/mg) and lower in mixed-humid/marine areas (14.8 EU/mg). Endotoxin predictors and endotoxin association with health outcomes significantly differed across climate regions. In subarctic/very cold/cold regions, log10 -endotoxin was significantly associated with higher prevalence of wheeze outcomes (OR:1.48, 95% CI:1.19–1.85 for any wheeze, OR:1.48, 95% CI:1.22–1.80 for exercise-induced wheeze, OR:1.50, 95% CI:1.13–1.98 for prescription medication for wheeze, and OR:1.95, 95% CI:1.50–2.54 for doctor/ER visit for wheeze). In hot-humid regions, log10 -endotoxin was positively associated with any wheeze (OR:1.66, 95% CI:1.04–2.65) and current asthma (OR:1.56, 95% CI:1.11–2.18), but negatively with sensitization to any inhalant allergens (OR:0.83, 95% CI:0.74–0.92). Conclusion: Endotoxin predictors and endotoxin association with asthma and wheeze differ across U.S. climate regions. Endotoxin is associated positively with wheeze or asthma in cold and hot-humid regions, but negatively with sensitization to inhalant allergens in hot-humid climates. Highlights: Endotoxin predictors and association with lung conditions differ with macroclimate. In cold regions, endotoxin is associated with higher prevalence of wheeze. In hot-humid regions, endotoxin is positively associated with wheeze and asthma. Endotoxin had an inverse relationship with sensitization in hot-humid climates.