Download or read book Mechanistic Studies on Metal-catalyzed Carbon-nitrogen Bond Forming Reactions written by Eric R. Strieter and published by . This book was released on 2005 with total page 330 pages. Available in PDF, EPUB and Kindle. Book excerpt: (Cont.) A systematic mechanistic analysis of Pd(OAc)2/ monophosphino- biaryl-catalyzed C-N bond forming reactions with aryl chlorides has been performed. The results provide insights into the relationship between the steady-state concentration of active Pd and the size and substitution pattern of the monophosphinobiaryl ligands. These insights into the nature of catalyst activation help highlight the importance of establishing a high concentration of active catalyst. The catalyst derived from the bulkiest ligand in the series, the tri-i-propyl ligand 13, exhibits both accelerated rate and the increased stability required for practical application of this reaction.