Download or read book Meta-analysis of Protein Structural Alignment written by Jim Havrilla and published by . This book was released on 2012 with total page 62 pages. Available in PDF, EPUB and Kindle. Book excerpt: The three-dimensional structure of a protein molecule provides significant insight into its biological function. Structural alignment of proteins is an important and widely performed task in the analysis of protein structures, whereby functionally and evolutionarily important segments are identified. However, structural alignment is a computationally difficult problem and a large number of heuristics introduced to solve it do not agree on their results. Consequently, there is no widely accepted solution to the structure alignment problem. In this study, we present a meta-analysis approach to generate a re-optimized, best-of-all result using the alignments generated from several popular methods. Evaluations of the methods on a large set of benchmark pairwise alignments indicate that TM-align provides superior alignments (except for RMSD), compared to other methods we have surveyed. Smolign provides smaller cores than other methods with best RMSD values. The re-optimization of the alignments using TM-align's optimization method does not alter the relative performance of the methods. We also provide visualization approaches to delineate the relationships of the alignment methods.