Post-Operative Neuropsychiatric Disorder

Post-Operative Neuropsychiatric Disorder
Author :
Publisher : Frontiers Media SA
Total Pages : 140
Release :
ISBN-10 : 9782832545911
ISBN-13 : 2832545912
Rating : 4/5 (11 Downloads)

Book Synopsis Post-Operative Neuropsychiatric Disorder by : Chun Yang

Download or read book Post-Operative Neuropsychiatric Disorder written by Chun Yang and published by Frontiers Media SA. This book was released on 2024-03-08 with total page 140 pages. Available in PDF, EPUB and Kindle. Book excerpt: Post-operative neuropsychiatric disorder (POND) is a series of neuropsychiatric symptoms strongly linked to the triggering factors, anesthesia, and surgery exposure. The clinical manifestations mainly include delirium, cognitive dysfunction, and affective disorders after surgeries. POND is the most frequent postoperative complication in elderly patients, especially those undergoing major surgery, such as cardiac and hip surgeries. It has been well recognized that oxidative stress, abnormal changes in neurotransmitters and synapses, as well as Aβ deposition, and phosphorylation of tau protein are probably involved in the mechanisms of POND. Although studies on the POND are in full swing, underlying pathogenesis is still ambiguous because of conflicting results and controversial evidence. Currently, patients with POND still fail to receive effective treatments, although clinical studies in this field have focused on these potential therapeutic targets in the last decades. Most importantly, more than 320 million people are scheduled to undergo surgeries every year globally, it is, therefore, an urgent need to develop and provide effective therapeutic strategies for patients with POND.


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