Download or read book The Role of Cell Types in Hepatocarcinogenesis written by Alphonse E. Sirica and published by CRC Press. This book was released on 1992-09-11 with total page 380 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Role of Cell Types in Hepatocarcinogenesis provides the first comprehensive, review and analysis of cell precursor relationships believed to be important in the development of hepatocellular carcinoma and other types of nonmesenchymal liver tumors. The book focuses on cell lineages in liver development and neoplastic formation in both experimental animal models and humans. It also critically reviews current information supporting the existence of a "facultative liver stem cell" and its potential role as an alternative cell of origin in the genesis of various hepatic neoplasms, including hepatocellular carcinoma. Other significant topics covered include cellular and viral oncogenes, p53 gene and growth factors in hepatocarcinogenesis, and the use of newly developed transgenic animal and cell culture models designed for investigating the pathogenesis of hepatocellular carcinoma. Numerous figures and tables illustrate difficult concepts, and an extensive listing of references is included. The Role of Cell Types in Hepatocarcinogenesis is a practical reference volume that basic and clinical researchers in liver carcinogenesis, development, and differentiation will find useful in their day-to-day work.